When comparing the levels of individual biomarkers before the surgery between all patients with appendicitis (n = 18) and those without (n = 22) using a Mann–Whitney test, significantly higher concentrations of both CRP (p = 0.008, and Me of 0.45 vs. 4.30) (Figure 1) and NGAL (p = 0.022, and Me of 33.99 vs. 46.15) (Figure 2) have been demonstrated. The gene discussed is CRP; the disease is appendicitis.