LAG-3 is overexpressed on tumor-infiltrating CD8+ T-cells in the TME of a wide range of solid tumors, such as ovarian cancer, renal cell carcinoma (RCC), hepatocellular carcinoma (HCC), melanoma, gastric cancer, follicular lymphoma (FL), non-small cell lung cancer (NSCLC), and head and neck squamous cell carcinoma (HNSCC) [39,40,41,42,43,44,45,46,47]. The gene discussed is CD8A; the disease is head and neck squamous cell carcinoma.