The co-expression of LAG-3 and PD-1 can result in exhausted and dysfunctional CD8+ T-cells; this was shown in NY-ESO-1 ovarian cancer samples where the synergy between LAG-3 and PD-1 generated dysfunctional CD8+ T-cells, reduced CD8+ T-cells activation, decreased cytokine release, and as a result an immune escape of tumor cells [43]. The gene discussed is PDCD1; the disease is neoplasm.