Moreover, high LAG-3 expression has been found in an extensive range of tumors including NSCLC, gastric cancer, colorectal cancer, breast cancer, ovarian cancer, HCC, RCC, FL, HNSCC, prostate cancer, pancreatic cancer, anal squamous cell carcinoma, and malignant pleural mesothelioma [40,41,42,43,44,45,58,59,60,61,62,63,64]. Here, LAG3 is linked to head and neck squamous cell carcinoma.