In multiple studies, YAP/TAZ and TEAD4 overexpression was detected in a diverse array of malignancies, engulfing lung and breast tumors, neoplasms of the gastrointestinal tract, extending from the esophageal to the colorectal region, as well as of the accessory glands (liver and pancreas), where it has been exclusively associated with detrimental prognosis and unfavorable clinicopathological parameters, such as higher tumor grade, advanced stages and resistance to treatment [34,35,36,37,38,39,40,41,42]. The gene discussed is TEAD4; the disease is breast neoplasm.