EGFR and glioblastoma: IDH-wildtype glioblastoma should be diagnosed in the setting of an IDH-wildtype diffuse and astrocytic glioma if there is (1) microvascular proliferation, (2) necrosis, or (3) telomerase reverse transcriptase (TERT) promoter mutation, or (4) epidermal growth factor receptor (EGFR) gene amplification, or 5) +7/−10 chromosome copy number changes [5].