IL1β, as a target for miR-34a-5p and miR-495-3p; ANXA3, as a target of miR-369-3p; PER1, as a target for miR-34a-5p and miR-370-3p; and FN1, as a target for miR-543, had significant up-regulation in HCC patients than healthy subjects (Figure 5B). This evidence concerns the gene IL1B and hepatocellular carcinoma.