Reports published on the genomic analysis of HPV(−) HNSCC demonstrated findings of mutations such as TP53, CDKN2A, MLL2/3, NOTCH1, PIK3CA, NSD1, FBXW7, DDR2, and CUL3 [13,15,17,18]. This evidence concerns the gene TP53 and head and neck squamous cell carcinoma.