ENPP2 and diabetes mellitus: In the studied BAV patients, the need for surgical replacement of the valve occurred in 28 patients; however, among the analyzed variables (concentration of IL-6, ATX, Lp(a), lipid profile parameters, diabetes, smoking, Lp(a) > 30 mg/dL, and Lp(a) > 50 mg/dL), only a high concentration of Lp(a) with a cut off 50 mg/dL was predictive of a shorter surgical-free survival (p = 0.016) (Figure 3).