Genetic “epileptic” models include Lgi1 (leucine-rich glioma-inactivated 1) knockout rats, which are a model of autosomal dominant lateral temporal epilepsy [157,158]; Scn1a1+/− (NaV1.1 sodium channel) knockout mice, which are a model of severe myoclonic epilepsy [159,160]; Sv2a (transmembrane glycoprotein) knockout mice, which experience lethal seizures [161]; 5-HT2C receptor–mutant mice, which also present infrequent and sporadic spontaneous seizures [162]; and other species (for a full review, see [163,164]). Here, LGI1 is linked to myoclonic epilepsy.