The triangular regulatory system comprising MITF, Nrf2, and p62 integrates antioxidant and autophagy mechanisms, increasing autophagy adaptor protein reserves while preventing transient autophagy surges caused by oxidative stress, thus contributing to the maintenance of autophagic flux in sepsis (Figure 8 A model for the anti-inflammatory and anti-oxidative mechanisms of the MITF–GAS5–miR-23 loop in sepsis vascular endothelium). The gene discussed is SQSTM1; the disease is Sepsis.