NGS studies showed some remarkable differences between NPM1-mut and NPM1-WT MDS: IDH1, IDH2, ASXL1, RUNX1, and TP53 mutations were less frequent in NPM1-mut MDS than in NPM1-WT MDS; PTPN11 and DNMT3A mutations were more frequent in NPM1-mut than in NPM1-WT MDS [73] (Figure 3). The gene discussed is DNMT3A; the disease is myelodysplastic syndrome.