NPM1 and myelodysplastic syndrome: These patients were predominantly classified as intermediate risk and high risk, with a median BM blast percentage of 10% and with a normal karyotype in 77% of cases; compared to the rest of the MDS patients, NPM1-mut MDS patients were younger, had lower hemoglobin levels, had a higher median BM blast percentage at diagnosis, and had a higher frequency of a normal karyotype [71].