Similarly, the combination of menin inhibitors with FLT3 inhibitors resulted in an enhanced inhibitory effect on the proliferation and stimulatory induction of apoptosis of primary FLT3-mut leukemic blasts [113] and of leukemia cells in a murine model of leukemia promoted by NPM1-mut and FLT3-ITD [114]. This evidence concerns the gene FLT3 and leukemia.