The analysis of both NPM1-mut and NPM1-WT AML patients showed that the presence of DNMT3A-R882 mutations was associated with a reduced overall survival compared to the respective DNMT3A-WT patients; in both NPM1-mut/DNMT3A-WT and NPM1-mut/DNMT3A-R882 AMLs, the co-occurrence of FLT3-ITD mutations, at both low and high allelic ratios, significantly reduced OS; triple-mutant NPM1/DNMT3A/FLT3-ITD patients showed a marked decline in OS [52]. Here, DNMT3A is linked to acute myeloid leukemia.