SMC3 and leukemia: Studies in inducible mouse models of NPM1-mut/SMC3-mut have shown that cohesin gene mutations alter the transcriptome in the context of the NPM1-mutant; in particular, it was shown that the Rac 1-2 exchange factor Dock1 is specifically upregulated in double-mutant NPM1/SMC3 cells and could represent a therapeutic target in these leukemias [63].