BCL2 and colorectal carcinoma: Additionally, Western blot analysis demonstrated upregulation of various pro-apoptotic proteins including c-PARP, c-caspase 3, BAX, and Mcl-1s, and downregulation of the anti-apoptotic proteins Bcl-2 and p-Akt in CRC cells treated with TG1, as compared to the control group (Figure 3C,D).