In breast cancer, a combination of THSG and ADM treatment increased the cell apoptosis by increasing apoptosis related markers including Bax/Bcl-2 and cleaved caspase-3/caspase-3 and decreasing vascular endothelial growth factor/phosphatidylinositol 3-kinase/Akt protein expression [27]. Here, AKT1 is linked to breast cancer.