MYC and cancer: Furthermore, we conducted Gene Set Enrichment Analysis (GSEA) of DEGs and found that the downregulated DEGs were enriched in HALLMARK_CHOLESTEROL_HOMEOSTASIS, HALLMARK_MYC_TARGETS_V1 and HALLMARK_MYC_TARGETS_V2 (Figure 5C), suggesting that TG1 may regulate cancer cell metabolism and influence cell survival by inhibiting MYC and its downstream effector molecules.