The present work identified a pattern of ADAMTS2 differential hypermethylation in heavy smoker subjects in comparison with controls in two neighboring CpGs corresponding to the cg02599361 and cg10208897 Illumina probes in the cancer-free subset (Table 2, Table 6, Tables S1 and S6), located in CpG islands in the gene body of ADAMTS2. This evidence concerns the gene ADAMTS2 and cancer.