BMPR1A and hepatocellular carcinoma: In human hepatoma cells and mouse models, matriptase-2 also cleaves other BMP receptors on the cell surface, including BMP receptor type 1A (also known as ALK3), activin receptor IIA (also known as ActRIIA), hemochromatosis protein, and transferrin receptor-2 that are important in the hepcidin induction pathway [62,101].