In muco-obstructive hyper tension, the inhibition of the KCa3.1 channel [5] and Kcnn4 silencing in ion transport and MCC in an animal model of CF/COPD-like muco-obstructive lung disease determined that Kcnn4 silencing enhances airway disease [5]. Here, KCNN4 is linked to chronic obstructive pulmonary disease.