Additionally, previous studies have shown that Timd4 and Clec4f are highly expressed in embryonically-derived KCs, but in NASH, the self-maintenance of embryonically-derived KCs is impaired, and the number of monocyte-derived KCs cells with low Timd4/Clef4f expression is increased [37,55]. The gene discussed is TBCE; the disease is metabolic dysfunction-associated steatohepatitis.