Likewise, our work shows increased expression of the intestinal oncofetal protein OCT4 in tumors with some degree of undifferentiation (moderately and poorly differentiated), which could lead to progression and even metastasis in RC, considering that it has been reported that the level of stem cell protein expression may be related to the content of these cells in the tumor and suggests its aggressiveness according to the degree of histological differentiation [39]. The gene discussed is POU5F1; the disease is neoplasm.