There is evidence that points to the expression of OCT4 in the regulation of various signaling pathways associated with tumor formation and malignant transformation and increased recurrence, such as p38 mitogen-activated protein kinase (MAPK)/caspase-3, Wnt/β-catenin, AKT, and Janus Kinase (JAK)/signal transducer and activator of transcription (STAT)3 signal pathways [45,46,47]. The gene discussed is MAPK14; the disease is neoplasm.