IFIH1 and viral infectious disease: Both interact with endosomal Toll-like receptor (TLR)-3 as well as with the cytoplasmic receptors, retinoic acid-inducible gene I (RIG-I), and melanoma differentiation-associated gene 5 (MDA-5), thereby mimicking a viral infection in inducing the secretion of type I interferon (IFN) and pro-inflammatory cytokines by antigen-presenting cells.