The immunopathogenesis of the progression of NASH to HCC in MUP-uPA mice is very similar to that in human NASH-driven HCC, with the precancerous liver accumulating PD-L1- and IL-10-expressing IgA+ cells in parallel with the appearance of inflammation-induced HCC progenitor cells [96]. This evidence concerns the gene IL10 and metabolic dysfunction-associated steatohepatitis.