CD177 and cancer: These hallmarks include (i) intracellular cancer cell characteristics (e.g., regulation of apoptosis and proliferation and metabolism, together with genomic instability), (ii) cell surface receptors for and release of components of the extracellular matrix in the cancer cell microenvironment, and (iii) mediators involved in cancer cell communication with neighboring cells in their microenvironment (endothelial cells/angiogenesis, immunomodulation, and invasion/metastasis).