CK2 is a regulatory molecule at all three levels of networks [56,61], and the function of CK2 as a regulator of Toll-like receptor 4 (TLR4)–NFκB pathway signaling can be used as an example of how CK2 inhibition influences AML cells through effects on all three levels of networks [75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101]. The gene discussed is NFKB1; the disease is acute myeloid leukemia.