Another study described that CK2 inhibition by apigenin alone has a proapoptotic effect, especially in primary AML cells with high CK2α levels [44], and their investigations of AML cell lines also suggest that CK2 inhibition by apigenin causes caspase cleavage, cytosolic release of Diablo, and mitochondrial release of Bax. This evidence concerns the gene DIABLO and acute myeloid leukemia.