Finally, this combined treatment decreased Wnt1, β-cathenin, Lrp6 (a coreceptor for Wnt), and Dvl levels in primary AML cells, and Mek1/2 and Erk1/2 phosphorylation were decreased as well as the phosphorylation of p65 NFκB. Here, NFKB1 is linked to acute myeloid leukemia.