AKT1 and acute myeloid leukemia: Examples of such pathways are nuclear factor-κB (NFκB), Janus kinase/signal transducer and activator of transcription (Jak–Stat), and PI3K–Akt–mTOR; these three pathways are all important in human AML development [3,7,8,9,10,11,12,13,14,15,16,17,18].