IKZF1 and acute myeloid leukemia: Their study showed that (i) CK2 inhibition decreased Ikaros phosphorylation and Bcl-xl expression, (ii) CK2 overexpression was associated with increased engraftment of xenotransplanted human AML cells, and this engraftment was inhibited by CX-4945 treatment; and (iii) CK2 inhibition increased Ikaros binding to the promoter region of the Bcl-xl gene and Ikaros then functioned as a repressor of Bcl-xl expression.