Activation of the KP is associated with suppression of the anti-tumor T cell response via local depletion tryptophan availability in the tumor microenvironment (TME) by IDO1, IDO2, or TDO as well as the generation of suppressive myeloid and T regulatory cells via ligation of the aryl hydrocarbon receptor (AHR) by Kyn and its metabolites [22,23]. Here, AHR is linked to neoplasm.