TIGIT and sarcoma: Other druggable immune checkpoint proteins such as CTLA4, TIGIT, IDO, LAG-3, and TIM-3, which are more frequently expressed in karyotypically complex sarcomas such as LMS than in their counterpart (karyotypically simple sarcomas), may be of relevant use; however, the prognostic and predictive value of these biomarkers have not been successfully demonstrated in sarcoma so far [43].