Focal prostatitis and granulomatous prostatitis may be indistinguishable from prostate cancer both on MRI, where they present as a focal lesion with low T2-signal, marked diffusion restriction, and early enhancement, and on clinical examination, where they present as a focal or diffuse area of stiffness of the gland and a raised PSA level [16]. The gene discussed is KLK3; the disease is prostate cancer.