DROSHA and pleuropulmonary blastoma: Eighty-eight DICER1 mutations were described for PPB; while most of these are in the regions encoding defined domains, such as helicase domains, the Dicer dimerization domain (DDD), the Piwi/Argonaute, Zwille (PAZ) domain, the RNase III domains, and the double-stranded RNA-binding domain, other mutations reside outside these domains [1].