CASP8 and cancer: Genes related to cancer processes, such as apoptosis (CASP1, CASP4, CASP7, CASP8, CASP10, SGK1 and TNFSF10), proliferation (STAT1, CD274, TNF, JUN), migration (GRB2), vesicle related genes (VAMP), MAPK (ATF3, JUN, GRB2) or Notch signaling pathways (STAT1) were shortlisted from the list of differentially expressed genes and used to establish a functional relationship using the String resource (Figure 3B) [26].