To evaluate the correlations of the expression levels of related genes among different HCC subgroups, we used MSigDB and recent studies to collect gene panels for HERV activation restriction, KRAB zinc finger proteins (KZFPs), RNA transport, stemness, metabolism, antiviral immunity, human leukocyte antigen (HLA) and antigen processing and presentation (APP), immune checkpoint, inflammasome and inflammatory response, and stimulated three prime antisense retroviral coding sequences (SPARCS). Here, APP is linked to hepatocellular carcinoma.