LEP and neoplasm: IL8 and LEP were up-regulated in tumour tissue (4.8-fold and 4.7-fold, respectively), while CXCL12, FGF2, LYVE2, NRP1, TIMP2, TIMP3, ENPP2, FBLN5, PDGFRB, TEK, and SERPINF1 were down-regulated in tumour tissue in comparison to morphologically normal tumour-adjacent tissue (Figure 2).