In premenopausal patients (n = 11; Figure 5A), six genes were statistically significantly down-regulated in tumour tissue compared to tumour-adjacent tissue: TIMP3 (13.1-fold), ENPP2 (11.4-fold), FGF2 (7.6-fold), CXCL12 (7.5-fold), TIMP2 (5.2-fold), and PDGFRB (4.9-fold change). This evidence concerns the gene TIMP3 and neoplasm.