Indeed, in our study, the expression of the LEP gene was significantly elevated in tumour tissue compared to patient-paired, morphologically normal, adjacent endometrial tissue (mean FR = 4.68; 95% CI 2.87–6.49; p = 0.0104; Table 4), which directly supports the hypothesis of leptin’s independent role in EC carcinogenesis. This evidence concerns the gene LEP and neoplasm.