CD8A and cancer: The analysis estimated that Cluster 3 was enriched in immune cells, including both immune reactive cells like CD4+ effector memory T-cells and CD8+ central memory T-cells as well as immuno-suppressive cells, such as macrophages, M1 macrophages, M2 macrophages, monocytes, myeloid dendritic cells, cancer-associated fibroblasts, and hematopoietic stem cells (Figure 5).