When cytotoxic T cells were subjected to AMP and subsequently redirected to kill EpCAM-expressing OC cells using EpCAM-directed/CD3-antagonistic bispecific antibody BIS-1, induction of cancer cell death, evident from high caspase-3/8 activation levels in target cells, significantly dropped (see Figure S8 for experimental setup). This evidence concerns the gene CASP3 and cancer.