In total, 3763 (5.8%) individuals developed at least 1 cancer during follow-up, and when comparing baseline characteristics between participants who developed a cancer during follow-up and those who did not, those with cancer were older at baseline (median age 48 [41, 56] years for those with cancer vs. 42 [35, 49] years for those without cancer; p < 0.0001) and had a lower median CD4 count (432 cells/mm3 [263, 635] vs. 472 [315, 663], p < 0.0001). The gene discussed is CD4; the disease is cancer.