Another investigation evaluated the significance of mortalin, Bcl-2, and Bax as prognostic factors in iCCA, and found that an increased level of Bcl-2 and mortalin and the down-regulation of Bax were linked to anti-apoptotic effects and tumor progression in iCCA [50]. The gene discussed is HSPA9; the disease is infantile convulsions and choreoathetosis.