PRSS1 and hereditary chronic pancreatitis: The same recommendations are provided by Cancer Research UK, according to which, screening should involve p high-risk individuals with hereditary pancreatitis and a defect in the PRSS1 gene, Peutz–Jeghers syndrome, or first-degree relatives with pancreatic cancer and those with a mutation in the BRCA1, BRCA2, PALB2, or CDKN2A genes.