STK11 and hamartoma: Peutz–Jeghers syndrome (PJS), inherited in an autosomal dominant manner, results from the mutation of the STK11/LKB1 gene and manifests as polyposis of the hamartoma type in the gastrointestinal tract and other organs; it increases the relative risk of pancreatic cancer up to 132 times, which is the highest risk among the genetic factors [11].