The immune-suppressive effect of SerpinB3, determining an impairment of the cytotoxic immune response was also described in oesophageal cancer, where SerpinB3 was inversely correlated to markers of immune activation, namely CD80, CD86, TLR4, and CD38 within the tumour, and with peritumoral expressions of CD8+ and CD107+ cells [126]. This evidence concerns the gene SERPINB3 and neoplasm.