Examples of validated targets include SP1, CDK4, AKT, and IRS1, while examples of predicted targets include skI, cyp2w1, CDK4, DNM2, ILK, ZNFR3, TXNIP, FADS1 VSIG2, CLCN5, and ALDH9A1, which are all involved in cancer progression [110]. This evidence concerns the gene SKI and cancer.