In a female-mouse lung-cancer model with a K-ras mutation and conditional deletion of Stat3, ER blockade increased the levels of immune suppression markers such as IL-6, CXCL2, and Foxp3 compared with those in control groups, and decreased the expression of immune genes, such as Ifng, Tbx21, and Gzmb, related to Th1 differentiation and the cytotoxic antitumor response. Here, KRAS is linked to lung carcinoma.