KRAS and lung cancer: In a female-mouse lung-cancer model with a K-ras mutation and conditional deletion of Stat3, ER blockade increased the levels of immune suppression markers such as IL-6, CXCL2, and Foxp3 compared with those in control groups, and decreased the expression of immune genes, such as Ifng, Tbx21, and Gzmb, related to Th1 differentiation and the cytotoxic antitumor response.