Hypomorphic mutations in RAD50 lead to NBS-like disorder (NBSLD-OMIM: 613078) characterized by facial features resembling NBS, severe prenatal growth retardation and persistent postnatal growth restriction, congenital microcephaly, mild to borderline intellectual disability, normal sexual development, radioresistant DNA synthesis, and no immunodeficiency or myelodysplasia or early neurodegeneration as key features. This evidence concerns the gene RAD50 and Nijmegen breakage syndrome-like disorder.