NBN and medulloblastoma: Moreover, in line with Cheung et al.’s study which found NOTCH pathway upregulation in lymphoblastoid cell lines from NBS heterozygous carriers [119], we recently published that Nbn heterozygosity increases the Notch pathway and a Notch-dependent clonogenicity in cerebellar granule cell progenitor (cGCPs) primary cultures, isolated from a Medulloblastoma (MB)-prone mouse model [120].