Overexpression of NBS1 induces EMT through the upregulation of the PI3-KINASE/AKT/SNAIL/MMP2 axis in HNSCC [127] and by MMP-2-independent expression of two heat shock proteins HSPA4 and HSPA14 in NSCLC [128]. This evidence concerns the gene MMP2 and head and neck squamous cell carcinoma.