Coherently, Na et al. reported that a C-terminally truncated MRE11 was responsible for the decreased HR repair and enhanced radiosensitivity in bladder cancer cells, suggesting that the increase in this truncated form of MRE11 might explain some of the paradoxical findings of high MRE11 expression associated with better survival rate after radiotherapy [149]. The gene discussed is MRE11; the disease is urinary bladder carcinoma.