PLK1 and prostate carcinoma: For example, CDC20 has been identified as a hub gene, alongside CDK1, in castration-resistant prostate cancer [55], and contributes to cell migration, disease progression and a poorer prognosis in metastatic prostate cancer [56] with another study showing that CDC20, alongside PLK1 and cyclin A, plays a critical role in prostate cancer metastasis [57].