RHOA and neoplasm: Overexpression and mutations of this gene are associated with tumor cell proliferation and metastasis in germinal center-derived B cell lymphomas, angioimmunoblastic T cell lymphoma, and gastric adenocarcinomas [110]; invasiveness and poor prognosis in colorectal cancers [111]; and reduced RHOA gene expression, in parallel with amplified signaling by the cytokines CCR5 and CXCR4, is associated with breast cancer metastasis [112].