TSC1 and neoplasm: The TSC1 (9q34) and TSC2 (16p13.3) genes encode two tumor suppressor subunits, TSC1–Subunit 1 or Hamartin (1164 amino acids; 129,767 Da) and TSC2–Subunit 2 or Tuberin (1807 amino acids; 200,608 Da) of the TSC complex, which negatively regulates anabolic cell growth.