In the embryonic period, abnormalities in NOTCH4 gene function due to mutations are associated with vascular defects and abnormal development of several organs, whereas in adulthood, they are identified in schizophrenia, hemangiomas, and breast cancers [135,136], and repeated allergen exposure leads to overexpression of NOTCH4, which contributes to asthma triggering. This evidence concerns the gene NOTCH4 and hemangioma.