The ALK gene (2p23.2-p23.1) encodes the ALK Receptor Tyrosine Kinase (1620 amino acids; 176,442 Da), which is part of the insulin receptor superfamily and receptor tyrosine kinases (RTKs), with an essential role in the development of the brain and specific neurons in the nervous system and whose abnormalities are present in neuroblastoma 3 and neuroblastoma. The gene discussed is ALK; the disease is neuroblastoma.