TGFBR1 and cancer: In these pathways, TGFBR1 is involved in G-phase cell cycle arrest in epithelial and hematopoietic cells, the regulation of cellular apoptosis, epithelial–mesenchymal transition, mesenchymal cell proliferation and differentiation, extracellular matrix synthesis, wound healing, immunosuppression, cancer cell invasion, and tumorigenesis.