TGFBR2 and goblet cell carcinoma: Mutations in the TGFBR2 gene are reported in a small number of cases of mucinous neoplasms of the appendix, with possible loss of function [7], and in less than 10% of cases of mucinous adenocarcinomas of the appendix, appendiceal adenocarcinomas, appendiceal goblet cell adenocarcinomas, low-grade appendiceal mucinous neoplasms, and signet ring cell adenocarcinomas of the appendix.