Next are appendiceal goblet cell adenocarcinomas, in which 29 mutated genes, KRAS, HRAS, NRAS, BRAF, ERBB2, MYC/cMYC, TP53, PTEN, CDKN1B, CDKN2A, RB1, APC, RHOA, GNAS, NOTCH1, TGFBR2, SMAD4, ARID1A, ARID2, ATM, CDH1, CTNNA1, CTNNB1, KDM6A, KMT2D, RHPN2, SOX9, TRRAP, and USP9X, and mucinous adenocarcinomas of the appendix, with 25 genes, KRAS, HRAS, NRAS, BRAF, ERBB2, FGFR1, FGFR2, FGFR3, KIT/cKIT, MYC/cMYC, TP53, PIK3CA, RB1, JAK3, APC, GNA11, GNAS, KDR/VEGFR2, TGFBR2, ARID1A, ATM, BRCA1, BRCA2, CDH1, FBXW7, and MUC16, in which mutations are identified. The gene discussed is KMT2D; the disease is mucinous adenocarcinoma of the appendix.