Defects in the TRRAP gene are found in some diseases, including developmental delay with/without dysmorphic facies and autism and autosomal dominant deafness 75, and dysregulations are reported in certain types of cancer, including glioblastoma multiforme [195], appendiceal adenocarcinomas, and appendiceal goblet cell adenocarcinomas [10]. Here, TRRAP is linked to goblet cell carcinoma.