Thus, TGFBR1*6A polymorphism, consisting of nine-base pair in-frame deletion within exon 1, and IVS7+24G>A polymorphism and TGFBR1 haploinsufficiency reduce TGFBR1 protein functionality, are correlated with tumor cell proliferation and early onset adenocarcinoma, and increase the risk of colon, colorectal, breast, and osteosarcoma cancers [143,144,145,146]. Here, TGFBR1 is linked to adenocarcinoma.