IDH1 and acute myeloid leukemia: Similarly, the recognition of leukemogenic mutations in IDH1 and IDH2 led to the development of IDH1 (ivosidenib (IVO), olutasidenib (OLUTA)) and IDH2 (enasidenib (ENA)) inhibitors to treat patients with AML harboring the respectively mutated IDH1 or IDH2 gene [11,12,13].