Thus, when SOX4 was overexpressed in glioblastoma cells, it was found to bind 126 tRNA genes, including all eight members of the tRNA-iMet-CAT-1 isodecoder family; although the binding of TFIIIC was unchanged at these genes, that of TFIIIB and pol III was diminished, and reduced expression was observed [77]. The gene discussed is SOX4; the disease is glioblastoma.