TP53 and breast cancer: Inactivation of TP53, a common event in breast cancers, may reduce mir-34a expression and thereby increase the stability of tRNA-iMet-CAU, perhaps boosting its levels relative to other tRNAs; this differential control, specific to one isoacceptor, would be additional to the general increase in tRNA gene transcription that accompanies the deletion or mutation of TP53 [60,65].