Within the discovery cohort, genome-wide significant (p < 5 × 10−8) susceptibility loci were observed in CN-AML and included SNP rs3997854 located in Major Histocompatibility Complex, Class II, DQ Alpha 2 (HLA-DQA2) gene (Chr 6p21.32) and rs75391980 (Chr 4q22.3). This evidence concerns the gene HLA-DQA2 and acute myeloid leukemia.