Validation of a fourth independent cohort (n = 977 cases, of which 465 were CN-AML, and n = 3728 controls) and meta-analysis confirmed the presence of rs4930561 in Lysine Methyltransferase 5B (KMT5B) gene on Chr 11q13.2 in all-AMLregardless of subtypes and rs3916765 in HLA-DQ2 (Chr 6p21.32) in CN-AML. The gene discussed is KMT5B; the disease is acute myeloid leukemia.