Molecular recognition of germline predisposition includes the following genetic susceptibility factors: RUNX family transcription factor 1 (RUNX1), CCAAT enhancer-binding protein α (CEBPA) and GATA binding protein 2 (GATA2); all of these proteins are regulatory transcription factors, impact hematopoiesis and have been associated with a younger age of AML onset [16,17]. The gene discussed is GATA2; the disease is acute myeloid leukemia.