Further meta-analysis of SNPs common to all four cohorts identified rs10789158 in Cache Domain Containing 1 (CACHD1) at Chr 1p31.1 risk locus in a consistent direction for all-AML and rs17773014 in the Aldo-Keto Reductase Family 1 Member B (AKR1B1) gene at Chr 7q33 for CN-AML. Here, CACHD1 is linked to acute myeloid leukemia.