IRF4 and acute myeloid leukemia: Patients from DISCOVeRY-BMT cohorts (2309 cases and 2814 controls) from the Center for International Blood and Marrow Transplant Research (CIBMTR) [53,54] were evaluated, and SNP rs12203592 located at Chr 6p25.3 within the interferon regulatory factor 4 (IRF4) gene was associated with an increased risk of de novo AML, de novo MDS and therapy-related MDS, but not therapy-related AML.