A similar phenomenon was reported by Pearlman et al., who found that 18.2% of eoCRC patients had a PGV not typically associated with CRC, including ATM, CHEK2 (classified as a less likely cause of CRC in this study), BRCA1, CDKN2A, and PALB2 [15]. Here, BRCA1 is linked to colorectal carcinoma.