Lung adenocarcinoma (LUAD) patients receiving epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapies undergo SCLC neuroendocrine transformation with RB1/TP53 mutations as well as enhancement of the PRC2 complex and PI3K/AKT pathways [5]. Here, TP53 is linked to small cell lung carcinoma.