It also affects the sensitivity of EGFR TKIs as cigarette smoke attenuates the AMP-activated protein-kinase (AMPK)-dependent inhibition of mTOR which then decreases the sensitivity of NSCLC cells with wild-type EGFR to TKI and thereby represses the expression of liver kinase B1 (LKB1) [17]. The gene discussed is STK11; the disease is non-small cell lung carcinoma.