ZNRF3 and adrenal cortex carcinoma: Interestingly, we observed a spectrum of Wnt/β-catenin signaling across ACC, with patient tumors bearing ligand-independent GOF mutations in β-catenin exhibiting the highest level of downstream Wnt signaling, whereas tumors with ligand-dependent LOF mutations in ZNRF3 exhibited more moderate Wnt/β-catenin activation, as previously observed [28].