CTNNB1 and adrenal cortex carcinoma: We tested two independent inhibitors of Wnt/β-catenin, PKF115-584 and Tegavivint, and demonstrated that both effectively repressed Wnt/β-catenin activity, decreased the expression of a distinct subset of ECM genes, and coordinately inhibited the in vitro growth of ACC cells harboring a CTNNB1 GOF mutation.