An Italian multicenter study on 273 aEOC—of whom 39.2% were germline BRCA1 or BRCA2 mutated (gBRCA1/2*)—reported higher incidences of peritoneal spread without ovarian mass (25.2% vs. 13.9%; p = 0.018), of bulky lymph nodes (30.8% vs. 17.5%; p = 0.010), and of peritoneal tumor load (laparoscopic predictive index value ≥8; 42.1% vs. 27.1%; p = 0.016) in gBRCA1/2* patients. Here, BRCA2 is linked to neoplasm.