In line with this finding, CRC tumor overexpression of MYBL2 was found to be within the top 10% of all DEGs identified in our analysis of TCGA-COAD, the second most significant within the purple module (only PCSK9 was more significantly associated with CRC), and within the top 35% of most connected genes within the module. Here, PCSK9 is linked to colorectal carcinoma.