TP53 and lung adenocarcinoma: This module was enriched for genes previously associated with tobacco exposure in lung adenocarcinoma [52], as well as cell cycle (GO:0007049, FDR = 5.73 × 1052), signal transduction in response to DNA damage (GO:0042770, FDR = 2.93 × 107), cellular response to DNA damage stimulus (GO:0006974, FDR = 2.00 × 106), DNA damage response, and signal transduction by p53 class mediator (GO:0030330, FDR = 1.59 × 105).