PCSK9 and colorectal carcinoma: Indeed, of the eight CRC GWAS loci found within this subset of CRC-related smoking genes, CDCA8 [80], CDKN3 [81], FADS1 [82], FADS2 [83], MYBL2 [84], PCSK9 [85], and PRC1 [86], have all been reported to be overexpressed in others cancers and to play important roles in the DNA damage response pathway.