Intriguingly, the inhibition of LSD1 potentiated an ATRA-driven differentiation of AML cell lines and primary cells together with the transcriptional activation of RAR target genes and also diminished the engraftment of primary AML samples in xenotransplantation models [7,124], suggesting that LSD1 is a promising target in combination with ATRA. This evidence concerns the gene KDM1A and acute myeloid leukemia.