In contrast, the DHG genes of H3K27ac-loss and down-regulated DEG expression (hDN-gDN) were related to cell proliferation (such as ribosome biogenesis in eukaryotes, pyrimidine metabolism, the cell cycle, and cellular senescence) and DNA replication and repair (the Fanconi anemia pathway and P53 signaling pathway) (Figure S6). The gene discussed is TP53; the disease is Fanconi anemia.