It has been shown that BRD4 is required for the activation of peroxisome proliferator-activated receptor gamma 2 (PPARγ2) and CCATT-enhancer-binding protein alpha (C/EBPα) gene transcription during adipocyte differentiation [52], affecting the lipid metabolism in the vascular cells, contribute to the pathogenesis of atherosclerosis. Here, BRD4 is linked to atherosclerosis.