NGB and Alzheimer disease: To circumvent these clinical limitations, Li et al. (2015) injected transgenic AD mice (APPswe/PSEN1dE9) with a plasmid containing neuroglobin (pNgb, 1 mg/mL) by ICV once a week for 8 weeks and showed a significant improvement in memory and cognition when animals were tested in the Morris water maze [123], accompanied by a reduction in amyloid burden in both the cortex and hippocampus compared to animals injected with the vector alone (pCDNA3.1).