In support of the previous findings, Chen et al. (2012), using an animal model of Alzheimer’s disease (Tg2576), showed that neuroglobin overexpression reduced levels of hyperphosphorylated tau (amino acids T231 and S369), with this mechanism dependent on AKT by reducing GSK3B activation [122]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.