Two years later, in 2014, Fernandez-Echevarria et al. confirmed the previous results showing that VDAC1 is associated with lipid rafts of neurons in AD patients, in addition to reporting that amyloid precursor protein (APP) interacts with VDAC1 in the frontal and entorhinal cortices of AD patients at earlier stages of the pathology [63]. Here, VDAC1 is linked to Alzheimer disease.